Anoop Patel

Associate Professor of Neurosurgery

Appointments and Affiliations

  • Associate Professor of Neurosurgery
  • Associate Professor in Pathology

Contact Information

  • Email Address: anoop.patel@duke.edu

Education

  • M.D. Harvard Medical School, 2009

Research Interests

My research lab focuses on using single-cell sequencing techniques to study intratumoral heterogeneity in malignant brain tumors. Intratumoral heterogeneity is the idea that individual cancer cells within a patient’s tumor are different and can respond differently to treatments. I also have an active interest in developing patient-specific models of disease where we can learn how an individual patient's tumor might respond differently than another. My ultimate goal is to further advance precision medicine approaches for malignant brain tumors, and ensure that patients are getting the right treatments for their specific tumors.

Representative Publications

  • Hardigan, Andrew A., Joshua D. Jackson, and Anoop P. Patel. “Surgical Management and Advances in the Treatment of Glioma.” Semin Neurol 43, no. 6 (December 2023): 810–24. https://doi.org/10.1055/s-0043-1776766.
  • Chartrand, Thomas, Rachel Dalley, Jennie Close, Natalia A. Goriounova, Brian R. Lee, Rusty Mann, Jeremy A. Miller, et al. “Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex.” Science 382, no. 6667 (October 13, 2023): eadf0805. https://doi.org/10.1126/science.adf0805.
  • Lee, Brian R., Rachel Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, et al. “Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex.” Science 382, no. 6667 (October 13, 2023): eadf6484. https://doi.org/10.1126/science.adf6484.
  • Singh, Kirit, Kelly M. Hotchkiss, Ian F. Parney, John De Groot, Solmaz Sahebjam, Nader Sanai, Michael Platten, et al. “Correcting the drug development paradigm for glioblastoma requires serial tissue sampling.” Nat Med 29, no. 10 (October 2023): 2402–5. https://doi.org/10.1038/s41591-023-02464-8.
  • Lerner, Emily C., Karolina I. Woroniecka, Vincent M. D’Anniballe, Daniel S. Wilkinson, Aditya A. Mohan, Selena J. Lorrey, Jessica Waibl-Polania, et al. “CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis.” Nat Cancer 4, no. 9 (September 2023): 1258–72. https://doi.org/10.1038/s43018-023-00600-4.