Craig Lowe


Assistant Professor of Molecular Genetics and Microbiology

Craig Lowe is an Assistant Professor in the Department of Molecular Genetics and Microbiology.  His research interests are in understanding how traits and characteristics of humans, and other vertebrates, are encoded in their genomes.  He is especially focused on adaptations and disease susceptibilities that are unique to humans.  To address these questions, Craig uses both computational and experimental approaches.  Craig's recent research has been on differences in how genes are regulated between species, or between different individuals within a species, and how this causes traits to differ.  All students in Craig's lab are exposed to an interdisciplinary environment; current lab members have backgrounds in mathematics, computer science, neuroscience, developmental biology, and genetics.  Each year Craig teaches one or two courses on rotating topics of: ancient DNA, ethical issues in genomics, and software development for genetic analyses.

Appointments and Affiliations

  • Assistant Professor of Molecular Genetics and Microbiology
  • Assistant Professor of Cell Biology
  • Member of the Duke Cancer Institute

Contact Information


  • Ph.D. University of California - Santa Cruz, 2010

Courses Taught

  • UPGEN 778A: University Program in Genetics and Genomics Biological Solutions Module I
  • UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il
  • UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill

In the News

Representative Publications

  • Pollen, AA; Kilik, U; Lowe, CB; Camp, JG, Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution., Nat Rev Genet, vol 24 no. 10 (2023), pp. 687-711 [10.1038/s41576-022-00568-4] [abs].
  • Au, EH; Fauci, C; Luo, Y; Mangan, RJ; Snellings, DA; Shoben, CR; Weaver, S; Simpson, SK; Lowe, CB, Gonomics: uniting high performance and readability for genomics with Go., Bioinformatics, vol 39 no. 8 (2023) [10.1093/bioinformatics/btad516] [abs].
  • Saelens, JW; Sweeney, MI; Viswanathan, G; Xet-Mull, AM; Jurcic Smith, KL; Sisk, DM; Hu, DD; Cronin, RM; Hughes, EJ; Brewer, WJ; Coers, J; Champion, MM; Champion, PA; Lowe, CB; Smith, CM; Lee, S; Stout, JE; Tobin, DM, An ancestral mycobacterial effector promotes dissemination of infection., Cell, vol 185 no. 24 (2022), pp. 4507-4525.e18 [10.1016/j.cell.2022.10.019] [abs].
  • Mangan, RJ; Alsina, FC; Mosti, F; Sotelo-Fonseca, JE; Snellings, DA; Au, EH; Carvalho, J; Sathyan, L; Johnson, GD; Reddy, TE; Silver, DL; Lowe, CB, Adaptive sequence divergence forged new neurodevelopmental enhancers in humans., Cell, vol 185 no. 24 (2022), pp. 4587-4603.e23 [10.1016/j.cell.2022.10.016] [abs].
  • Wucherpfennig, JI; Howes, TR; Au, JN; Au, EH; Roberts Kingman, GA; Brady, SD; Herbert, AL; Reimchen, TE; Bell, MA; Lowe, CB; Dalziel, AC; Kingsley, DM, Evolution of stickleback spines through independent cis-regulatory changes at HOXDB., Nature Ecology and Evolution, vol 6 no. 10 (2022), pp. 1537-1552 [10.1038/s41559-022-01855-3] [abs].