Pranam D. Chatterjee


Assistant Professor of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor of Biomedical Engineering
  • Assistant Professor in Biostatistics & Bioinformatics
  • Assistant Professor of Computer Science

Contact Information

  • Office Location: 101 Science Drive, CIEMAS 2353A, Durham, NC 27705
  • Email Address:
  • Websites:


  • Ph.D. Massachusetts Institute of Technology, 2020

Research Interests

Integration of computational and experimental methodologies to design novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering

Courses Taught

  • BME 390L: Special Topics with a Lab
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • EGR 393: Research Projects in Engineering

In the News

Representative Publications

  • Chen, T; Hong, L; Yudistyra, V; Vincoff, S; Chatterjee, P, Generative design of therapeutics that bind and modulate protein states, Current Opinion in Biomedical Engineering, vol 28 (2023) [10.1016/j.cobme.2023.100496] [abs].
  • Zhao, L; Koseki, SRT; Silverstein, RA; Amrani, N; Peng, C; Kramme, C; Savic, N; Pacesa, M; Rodríguez, TC; Stan, T; Tysinger, E; Hong, L; Yudistyra, V; Ponnapati, MR; Jacobson, JM; Church, GM; Jakimo, N; Truant, R; Jinek, M; Kleinstiver, BP; Sontheimer, EJ; Chatterjee, P, PAM-flexible genome editing with an engineered chimeric Cas9., Nature Communications, vol 14 no. 1 (2023) [10.1038/s41467-023-41829-y] [abs].
  • Brixi, G; Ye, T; Hong, L; Wang, T; Monticello, C; Lopez-Barbosa, N; Vincoff, S; Yudistyra, V; Zhao, L; Haarer, E; Chen, T; Pertsemlidis, S; Palepu, K; Bhat, S; Christopher, J; Li, X; Liu, T; Zhang, S; Petersen, L; DeLisa, MP; Chatterjee, P, SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders., Communications Biology, vol 6 no. 1 (2023) [10.1038/s42003-023-05464-z] [abs].
  • Bhat, S; Palepu, K; Yudistyra, V; Hong, L; Kavirayuni, VS; Chen, T; Zhao, L; Wang, T; Vincoff, S; Chatterjee, P, De NovoGeneration and Prioritization of Target-Binding Peptide Motifs from Sequence Alone (2023) [10.1101/2023.06.26.546591] [abs].
  • Liang, S-Q; Liu, P; Ponnienselvan, K; Suresh, S; Chen, Z; Kramme, C; Chatterjee, P; Zhu, LJ; Sontheimer, EJ; Xue, W; Wolfe, SA, Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag., Nature Methods, vol 20 no. 6 (2023), pp. 898-907 [10.1038/s41592-023-01859-2] [abs].