Simon Gray Gregory

Gregory

Professor in Neurosurgery

Dr. Gregory is a tenured Professor and Director of the Brain Tumor Omics Program (BTOP) in the Duke Department of Neurosurgery, the Vice Chair of Research in the Department of Neurology, and Director of the Molecular Genomics Core at the Duke Molecular Physiology Institute. 

As a neurogenomicist, Dr. Gregory applies the experience gained from leading the sequencing of chromosome 1 for the Human Genome Project to elucidating the mechanisms underlying multi-factorial diseases using genetic, genomic, and epigenetic approaches. Dr. Gregory’s primary areas of research involve understanding the molecular processes associated with disease development and progression in brain tumors and Alzheimer’s disease, novel drug induced white matter injury repair in multiple sclerosis, and social and behavioral response to oxytocin treatment animal models of autism. 

He is broadly regarded across Duke as a leader in the development of novel single cell and spatial molecular technologies towards understanding the pathogenic mechanisms of disease development. Dr. Gregory is also the Section Chair of Genomics and Epigenetics at the DMPI and Director of the Duke Center of Autoimmunity and MS in the Department of Neurology.

Appointments and Affiliations

  • Professor in Neurosurgery
  • Vice Chair for Research in the Department of Neurology
  • Professor in Molecular Genetics and Microbiology
  • Professor in Neurology
  • Member of the Duke Cancer Institute
  • Member of Duke Molecular Physiology Institute

Contact Information

Education

  • Ph.D. Open University, Milton Keynes (United Kingdom), 2003
  • B.A.Sc. RMIT University (Australia), 1990

Research Interests

Brain tumors

Multiple Sclerosis

Autism

Alzheimer Disease

Application of single cell and spatial technologies to basic and translational research

Awards, Honors, and Distinctions

  • Nominated, Outstanding Postdoc Mentor. Duke University. 2015
  • Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
  • Breakthrough Research Award. North Carolina Health & Life Science. 2010
  • Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007

Courses Taught

  • CRP 243: Introduction to Medical Genetics
  • MGM 593: Research Independent Study
  • UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill
  • UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV

In the News

Representative Publications

  • Minear, MA; Crosslin, DR; Sutton, BS; Connelly, JJ; Nelson, SC; Gadson-Watson, S; Wang, T; Seo, D; Vance, JM; Sketch, MH; Haynes, C; Goldschmidt-Clermont, PJ; Shah, SH; Kraus, WE; Hauser, ER; Gregory, SG, Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease., Hum Genet, vol 129 no. 6 (2011), pp. 641-654 [10.1007/s00439-011-0959-z] [abs].
  • Evsyukova, I; Somarelli, JA; Gregory, SG; Garcia-Blanco, MA, Alternative splicing in multiple sclerosis and other autoimmune diseases., Rna Biol, vol 7 no. 4 (2010), pp. 462-473 [10.4161/rna.7.4.12301] [abs].
  • Gregory, SG; Connelly, JJ; Towers, AJ; Johnson, J; Biscocho, D; Markunas, CA; Lintas, C; Abramson, RK; Wright, HH; Ellis, P; Langford, CF; Worley, G; Delong, GR; Murphy, SK; Cuccaro, ML; Persico, A; Pericak-Vance, MA, Genomic and epigenetic evidence for oxytocin receptor deficiency in autism., Bmc Medicine, vol 7 (2009) [10.1186/1741-7015-7-62] [abs].
  • Connelly, JJ; Shah, SH; Doss, JF; Gadson, S; Nelson, S; Crosslin, DR; Hale, AB; Lou, X; Wang, T; Haynes, C; Seo, D; Crossman, DC; Mooser, V; Granger, CB; Jones, CJH; Kraus, WE; Hauser, ER; Gregory, SG, Genetic and functional association of FAM5C with myocardial infarction., Bmc Medical Genetics, vol 9 (2008) [10.1186/1471-2350-9-33] [abs].
  • Gregory, SG; Schmidt, S; Seth, P; Oksenberg, JR; Hart, J; Prokop, A; Caillier, SJ; Ban, M; Goris, A; Barcellos, LF; Lincoln, R; McCauley, JL; Sawcer, SJ; Compston, DAS; Dubois, B; Hauser, SL; Garcia-Blanco, MA; Pericak-Vance, MA; Haines, JL; Multiple Sclerosis Genetics Group,, Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis., Nature Genetics, vol 39 no. 9 (2007), pp. 1083-1091 [10.1038/ng2103] [abs].
  • Connelly, JJ; Wang, T; Cox, JE; Haynes, C; Wang, L; Shah, SH; Crosslin, DR; Hale, AB; Nelson, S; Crossman, DC; Granger, CB; Haines, JL; Jones, CJH; Vance, JM; Goldschmidt-Clermont, PJ; Kraus, WE; Hauser, ER; Gregory, SG, GATA2 is associated with familial early-onset coronary artery disease., Plos Genet, vol 2 no. 8 (2006) [10.1371/journal.pgen.0020139] [abs].
  • Schmidt, S; Pericak-Vance, MA; Sawcer, S; Barcellos, LF; Hart, J; Sims, J; Prokop, AM; van der Walt, J; DeLoa, C; Lincoln, RR; Oksenberg, JR; Compston, A; Hauser, SL; Haines, JL; Gregory, SG; Multiple Sclerosis Genetics Group,, Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis., Genes and Immunity, vol 7 no. 5 (2006), pp. 384-392 [10.1038/sj.gene.6364311] [abs].
  • Gregory, SG; Barlow, KF; McLay, KE; Kaul, R; Swarbreck, D; Dunham, A; Scott, CE; Howe, KL; Woodfine, K; Spencer, CCA; Jones, MC; Gillson, C; Searle, S; Zhou, Y; Kokocinski, F; McDonald, L; Evans, R; Phillips, K; Atkinson, A; Cooper, R; Jones, C; Hall, RE; Andrews, TD; Lloyd, C; Ainscough, R; Almeida, JP; Ambrose, KD; Anderson, F; Andrew, RW; Ashwell, RIS; Aubin, K; Babbage, AK; Bagguley, CL; Bailey, J; Beasley, H; Bethel, G; Bird, CP; Bray-Allen, S; Brown, JY; Brown, AJ; Buckley, D; Burton, J; Bye, J; Carder, C; Chapman, JC; Clark, SY; Clarke, G; Clee, C; Cobley, V; Collier, RE; Corby, N; Coville, GJ; Davies, J; Deadman, R; Dunn, M; Earthrowl, M; Ellington, AG; Errington, H; Frankish, A; Frankland, J; French, L; Garner, P; Garnett, J; Gay, L; Ghori, MRJ; Gibson, R; Gilby, LM; Gillett, W; Glithero, RJ; Grafham, DV; Griffiths, C; Griffiths-Jones, S; Grocock, R; Hammond, S; Harrison, ESI; Hart, E; Haugen, E; Heath, PD; Holmes, S; Holt, K; Howden, PJ; Hunt, AR; Hunt, SE; Hunter, G; Isherwood, J; James, R; Johnson, C; Johnson, D; Joy, A; Kay, M; Kershaw, JK; Kibukawa, M; Kimberley, AM; King, A; Knights, AJ; Lad, H; Laird, G; Lawlor, S; Leongamornlert, DA; Lloyd, DM; Loveland, J; Lovell, J; Lush, MJ; Lyne, R; Martin, S; Mashreghi-Mohammadi, M; Matthews, L; Matthews, NSW; McLaren, S; Milne, S; Mistry, S; Moore, MJF; Nickerson, T; O'Dell, CN; Oliver, K; Palmeiri, A; Palmer, SA; Parker, A; Patel, D; Pearce, AV; Peck, AI; Pelan, S; Phelps, K; Phillimore, BJ; Plumb, R; Rajan, J; Raymond, C; Rouse, G; Saenphimmachak, C; Sehra, HK; Sheridan, E; Shownkeen, R; Sims, S; Skuce, CD; Smith, M; Steward, C; Subramanian, S; Sycamore, N; Tracey, A; Tromans, A; Van Helmond, Z; Wall, M; Wallis, JM; White, S; Whitehead, SL; Wilkinson, JE; Willey, DL; Williams, H; Wilming, L; Wray, PW; Wu, Z; Coulson, A; Vaudin, M; Sulston, JE; Durbin, R; Hubbard, T; Wooster, R; Dunham, I; Carter, NP; McVean, G; Ross, MT; Harrow, J; Olson, MV; Beck, S; Rogers, J; Bentley, DR; Banerjee, R; Bryant, SP; Burford, DC; Burrill, WDH; Clegg, SM; Dhami, P; Dovey, O; Faulkner, LM; Gribble, SM; Langford, CF; Pandian, RD; Porter, KM; Prigmore, E, The DNA sequence and biological annotation of human chromosome 1., Nature, vol 441 no. 7091 (2006), pp. 315-321 [10.1038/nature04727] [abs].
  • Gregory, SG; Sekhon, M; Schein, J; Zhao, S; Osoegawa, K; Scott, CE; Evans, RS; Burridge, PW; Cox, TV; Fox, CA; Hutton, RD; Mullenger, IR; Phillips, KJ; Smith, J; Stalker, J; Threadgold, GJ; Birney, E; Wylie, K; Chinwalla, A; Wallis, J; Hillier, L; Carter, J; Gaige, T; Jaeger, S; Kremitzki, C; Layman, D; Maas, J; McGrane, R; Mead, K; Walker, R; Jones, S; Smith, M; Asano, J; Bosdet, I; Chan, S; Chittaranjan, S; Chiu, R; Fjell, C; Fuhrmann, D; Girn, N; Gray, C; Guin, R; Hsiao, L; Krzywinski, M; Kutsche, R; Lee, SS; Mathewson, C; McLeavy, C; Messervier, S; Ness, S; Pandoh, P; Prabhu, A-L; Saeedi, P; Smailus, D; Spence, L; Stott, J; Taylor, S; Terpstra, W; Tsai, M; Vardy, J; Wye, N; Yang, G; Shatsman, S; Ayodeji, B; Geer, K; Tsegaye, G; Shvartsbeyn, A; Gebregeorgis, E; Krol, M; Russell, D; Overton, L; Malek, JA; Holmes, M; Heaney, M; Shetty, J; Feldblyum, T; Nierman, WC; Catanese, JJ; Hubbard, T; Waterston, RH; Rogers, J; de Jong, PJ; Fraser, CM; Marra, M; McPherson, JD; Bentley, DR, A physical map of the mouse genome., Nature, vol 418 no. 6899 (2002), pp. 743-750 [10.1038/nature00957] [abs].