In the News

Astrocytes are highly complex cells that tightly envelope synaptic structures in the brain. This picture shows 3D-printed forms of astrocytes

November 12, 2020 | Duke Today

Astrocytes Identified as Master ‘Conductors’ of the Brain

Star-shaped ‘glue’ cells make it their business to govern connections between neurons

mini lung

October 23, 2020 | Duke Today

Lab-grown Mini-lungs Mimic the Real Thing – Right Down to COVID Infection

Living human lung air sacs in tiny dishes promise to accelerate COVID research

crystal structure of DNA

October 22, 2020 | Duke School of Medicine

Transcription factors may inadvertently lock in DNA mistakes

Transcription factor proteins are the light switches of the human genome.

Yarui Diao

September 23, 2020

Diao receives $3 million grant from 4D Nucleome Consortium

Yarui Diao, Ph.D. received a U01 grant, totaling $3 million in research funding for 5 years, from 4D Nucleome Consortium (phase 2) through the NIH Common fund. Diao aims to determine the function and regulation of high-order chromatin structure on gene regulation and [...]

Purushothama Rao Tata

September 16, 2020 | Duke University

Lung Stem Cells in Transition - a Culprit in Lung Fibrosis

artistic rendering of DNA on black background

September 9, 2020

Diao awarded Genomic Innovator Awards

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, selected Yarui Diao to receive 2020 Genomic Innovator Awards. NHGRI honored a total of 12 early career investigators in genomics.

Yarui Diao

September 1, 2020 | Duke School of Medicine

Diao awarded 2020 Genomic Innovator Award

Ken Poss

June 22, 2020 | Development

An interview with Ken Poss

Ken Poss recently joined the Development team as associate editor, focusing on the field of regenerative biology. Development interviewed him to find out more about his career, research, and why he decided to get involved with the journal.  

Yarui Diao

June 19, 2020

Cancer: The wound that never heals

Yarui Diao is trying to shed more light on rhabdomyosarcoma in an effort to come up with better treatment options.

April 21, 2020 | Duke Research Blog

Asokan, Gersbach research highlighted by Vice President of Research

Dr. Carin reflects on how Duke's fundamental research can turn viruses into marvels.

Circos plot displaying data from drug-modifier CRISPR screens. The screen conducted in the presence of ABT-199 is shown as a cutout with annotations from the outermost rim: genes ranked from most sensitizing (rank = 1) to most resisting (rank = 2,390); scatter plot of corresponding gene essentiality score; drug-modifier score (shown in replicate), colored to depict sensitizers (red) and resisters (blue). Gene–gene relationships that exhibit AP between drug screens are indicated by purple connections.

March 31, 2020

Setting a trap for drug-resistant cancers

By Alissa Kocer A cancer patient and his family sit in a doctor’s office waiting to see how well he is responding to treatment. As the doctor pulls up his scans, all of the air in the room seems to vanish. When the doctor says, “Your tumor has shrunk and is almost gone!” A [...]

Congratulations MEDx Colloquia award recipients: Charlie Gersbach, Edward Smith, Simon Gregor, Xiling Shen, Jessilyn Dunn, Raluca Gordon

March 5, 2020

Four CAGT Faculty among MEDx Coloquia Award recipients

Four CAGT faculty are represented in the 2020 MEDxColloquia Awards. These colloquia are designed to bring together physicians, engineers, computer scientists, data analysts, and basic and/or clinical researchers with a desire to pursue an interdisciplinary approach to solve complex problems and inspire innovation in medicine.

headshots of maria ciofani and kris wood

February 28, 2020

Ciofani and Wood receive tenure

Center for Advanced Genomic Technologies Steering Committee Members Maria Ciofani and Kris Wood have recently been awarded tenure. Congratulations to you both! 

The Duke Center for Advanced Genomic Technologies aims to investigate and re-engineer the inner workings of cellular gene regulation machinery and networks

January 2, 2020 | Duke Engineering News

Duke Researchers Garner Over $6 Million in NIH Funding to Fight Genetic Diseases

Collaborative work using CRISPR genome editing to address the burden of genetic neuromuscular diseases flourishes across Duke.

December 13, 2019 | Duke Engineering News

A Window into the Hidden World of Colons

Combining a skin-level glass window with a gut-stabilizing magnet, researchers get a view into the colon of a live animal

headshots of charlie gersbach and greg crawford

November 19, 2019

Greg Crawford and Charlie Gersbach Recognized as Highly Cited Researchers

Each year, the Web of Science Group identifies the world’s most influential researchers. The select few who have been most frequently cited by their peers over the last decade. In 2019, fewer than 6,300, or 0.1%, of the world's researchers, across 21 research fields, have [...]

two strands of DNA

November 15, 2019 | BioSpace

Sarepta and StrideBio Announce Multi-target Strategic Collaboration to Advance Novel Gene Therapies

Sarepta Therapeutics, Inc., the leader in precision genetic medicine for rare diseases, and StrideBio, Inc., a leading developer of novel adeno-associated viral (AAV) based gene therapies, will collaborate to develop in vivo AAV-based therapies for up to eight central nervous system and neuromuscular targets.

Cartoon crystal structure of the TALEN gene editing technology. (Credit: Gersbach Lab)

November 4, 2019 | Duke Engineering News

The Evolution of Genetic Engineering

A Q&A with Charles Gersbach

October 14, 2019 | Duke GCB News

Weapon of Mass Congestion: Protection from Influenza Virus through Gene Control

DARPA recently awarded a grant to a Duke team for a multifaceted research effort aimed at temporarily regulating gene expression using RNA-based techniques that could help protect against pandemic flu by boosting lung resistance to the virus, attacking the virus directly, enhancing the immune system response and improving the effects of existing vaccines.

The Duke Center for Advanced Genomic Technologies aims to investigate and re-engineer the inner workings of cellular gene regulation machinery and networks

September 30, 2019 | Duke Engineering News

New Duke Center Takes Aim at the Dark Genome

Spanning Duke University and Duke Health, the Center for Advanced Genomic Technologies will use homegrown tools and techniques to discover potential therapies for human diseases from autism to cancer to schizophrenia


September 23, 2019 | Duke Engineering News

New CRISPR Class Expands Genetic Engineering Toolbox

In a recent study, Charles Gersbach and Adrian Oliver, a post-doctoral fellow in the Gersbach lab who led the project, describe how they successfully harnessed Class 1 CRISPR systems to turn target genes on and off and edit the epigenome in human cells for the first time.

Dewran Kocak

August 30, 2019

Caught Happily Between Labs

As a late-stage Ph.D. student, I find myself in a unique position to reflect on the culture here at Duke. It’s an exciting time to be a scientist, especially as my mentors join together with other research groups to launch the Center for Advanced Genomic Technologies (CAGT [...]

Kris Wood

April 23, 2019 | Illumina

Kris Wood's company Celldom accepted into Illumina Accelerator

Celldom, cofounded by Kris Wood, Zachary Forbes, and Bejamin Yellen, is a research tools company developing next generation, single-cell analysis technology to advance research and drug discovery and development by illuminating diversity in cell populations.

An artist’s representation of the CRISPR/Cas9 genetic sequence with the “hairpin” lock added to the left side of the system, which increases its precision by an average of 50-fold.

April 15, 2019 | Duke Engineering News

Engineering "Hairpins" Increases CRISPR Accuracy

An added piece of RNA could improve the precision of CRISPR 50-fold.