Bill Majoros


Assistant Professor of Biostatistics & Bioinformatics

William H. Majoros, PhD, is an Assistant Professor of Biostatistics and Bioinformatics.

Appointments and Affiliations

  • Assistant Professor of Biostatistics & Bioinformatics

Contact Information

  • Office Location: 3 Genome Court, 1247 MSRB III, Durham, NC 27710
  • Office Phone: (919) 308-4228
  • Email Address:


  • Ph.D. Duke University, 2017

Research Interests

  • Probabilistic machine learning
  • Bayesian graphical models
  • Structured prediction
  • Interpretation/prioritization of genetic variants in disease
  • RNA splicing
  • Gene regulation
  • Computational linguistics - formal grammars and parsing
  • Syntactic structure and memetic evolution in complex bird song

Courses Taught

  • BIOSTAT 914: Graphical Models for Biological Data
  • CBB 914: Graphical Models for Biological Data

Representative Publications

  • Majoros, WH; Kim, Y-S; Barrera, A; Li, F; Wang, X; Cunningham, SJ; Johnson, GD; Guo, C; Lowe, WL; Scholtens, DM; Hayes, MG; Reddy, TE; Allen, AS, Bayesian estimation of genetic regulatory effects in high-throughput reporter assays., Bioinformatics, vol 36 no. 2 (2020), pp. 331-338 [10.1093/bioinformatics/btz545] [abs].
  • Edsall, LE; Berrio, A; Majoros, WH; Swain-Lenz, D; Morrow, S; Shibata, Y; Safi, A; Wray, GA; Crawford, GE; Allen, AS, Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach., Genome Biology and Evolution, vol 11 no. 10 (2019), pp. 3035-3053 [10.1093/gbe/evz218] [abs].
  • Johnson, GD; Barrera, A; McDowell, IC; D'Ippolito, AM; Majoros, WH; Vockley, CM; Wang, X; Allen, AS; Reddy, TE, Human genome-wide measurement of drug-responsive regulatory activity., Nature Communications, vol 9 no. 1 (2018) [10.1038/s41467-018-07607-x] [abs].
  • Majoros, WH; Holt, C; Campbell, MS; Ware, D; Yandell, M; Reddy, TE, Predicting gene structure changes resulting from genetic variants via exon definition features., Bioinformatics, vol 34 no. 21 (2018), pp. 3616-3623 [10.1093/bioinformatics/bty324] [abs].
  • McDowell, IC; Barrera, A; D'Ippolito, AM; Vockley, CM; Hong, LK; Leichter, SM; Bartelt, LC; Majoros, WH; Song, L; Safi, A; Koçak, DD; Gersbach, CA; Hartemink, AJ; Crawford, GE; Engelhardt, BE; Reddy, TE, Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding., Genome Res, vol 28 no. 9 (2018), pp. 1272-1284 [10.1101/gr.233346.117] [abs].