Presenter: Frank Conlon, PhD
The Colon laboratory is increasingly focused on elucidating how biological sex shapes cardiac development and disease susceptibility. Our group is conducting studies to define how sex-specific regulatory programs influence gene networks that pattern the embryonic heart and contribute to differential vulnerability to structural and functional cardiac disorders across the lifespan. A newer and expanding area of investigation centers on X-chromosome dosage biology, including the role of genes that escape X-inactivation in the heart as potential drivers of sex-biased developmental and disease phenotypes. From these studies, our lab seeks to identify sex-informed regulatory pathways that help explain and ultimately predict sex differences in both congenital and acquired heart disease.
Contact
Franklin, Monica
(919) 668-1049
monica.franklin@duke.edu