Anne Elizabeth West


Professor of Neurobiology

The long term goal of our laboratory is to understand at a cellular/molecular level how neuronal activity regulates the formation and maturation of synapses during brain development, and ultimately to use genetic model systems to understand how defects in this developmental process lead to cognitive dysfunction.

Appointments and Affiliations

  • Professor of Neurobiology
  • Faculty Network Member of the Duke Institute for Brain Sciences
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: Bryan Research Building, 311 Research Drive Room 301D, Durham, NC 27710
  • Office Phone: (919) 681-1909
  • Email Address:
  • Websites:


  • Ph.D. Harvard University , 1998
  • M.D. Harvard University , 1998
  • B.A. Cornell University, 1989

Courses Taught

  • NEUROBIO 393: Research Independent Study
  • NEUROBIO 719: Concepts in Neuroscience I: Cellular and Molecular Neurobiology
  • NEUROBIO 719A: Neuronal Excitability
  • NEUROBIO 719B: Cell Biology of the Neuron
  • NEUROBIO 719C: Synaptic Transmission
  • NEUROBIO 719D: Neural Plasticity
  • NEUROBIO 719E: Neural Development
  • NEUROBIO 726S: Neurobiology Journal Club
  • NEUROBIO 793: Research in Neurobiology
  • NEUROSCI 493: Research Independent Study 1
  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 495: Research Independent Study 3

In the News

Representative Publications

  • Gemberling, MP; Siklenka, K; Rodriguez, E; Tonn-Eisinger, KR; Barrera, A; Liu, F; Kantor, A; Li, L; Cigliola, V; Hazlett, MF; Williams, CA; Bartelt, LC; Madigan, VJ; Bodle, JC; Daniels, H; Rouse, DC; Hilton, IB; Asokan, A; Ciofani, M; Poss, KD; Reddy, TE; West, AE; Gersbach, CA, Transgenic mice for in vivo epigenome editing with CRISPR-based systems., Nat Methods, vol 18 no. 8 (2021), pp. 965-974 [10.1038/s41592-021-01207-2] [abs].
  • Chan, U; Gautam, D; West, AE, Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development., Journal of Visualized Experiments : Jove no. 172 (2021) [10.3791/62568] [abs].
  • Green, MV; West, AE, TRPing into excitotoxic neuronal death., Cell Calcium, vol 93 (2021) [10.1016/j.ceca.2020.102331] [abs].
  • Chen, L-F; Lyons, MR; Liu, F; Green, MV; Hedrick, NG; Williams, AB; Narayanan, A; Yasuda, R; West, AE, The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription., The Journal of Biological Chemistry, vol 295 no. 25 (2020), pp. 8613-8627 [10.1074/jbc.RA119.010266] [abs].
  • Nord, AS; West, AE, Neurobiological functions of transcriptional enhancers., Nat Neurosci, vol 23 no. 1 (2020), pp. 5-14 [10.1038/s41593-019-0538-5] [abs].