Aravind Asokan

Asokan

Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Biomedical Engineering
  • Professor of Molecular Genetics and Microbiology
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. University of North Carolina - Chapel Hill, 2004

Research Interests

Virology
RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Courses Taught

  • BME 791: Graduate Independent Study
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study

Representative Publications

  • Emmanuel, SN; Smith, JK; Hsi, J; Tseng, Y-S; Kaplan, M; Mietzsch, M; Chipman, P; Asokan, A; McKenna, R; Agbandje-McKenna, M, Structurally Mapping Antigenic Epitopes of Adeno-Associated Virus 9: Development of Antibody Escape Variants., J Virol (2021) [10.1128/JVI.01251-21] [abs].
  • Pickar-Oliver, A; Gough, V; Bohning, JD; Liu, S; Robinson-Hamm, JN; Daniels, H; Majoros, WH; Devlin, G; Asokan, A; Gersbach, CA, Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy., Molecular Therapy : the Journal of the American Society of Gene Therapy, vol 29 no. 11 (2021), pp. 3243-3257 [10.1016/j.ymthe.2021.09.003] [abs].
  • Elmore, ZC; Patrick Havlik, L; Oh, DK; Anderson, L; Daaboul, G; Devlin, GW; Vincent, HA; Asokan, A, The membrane associated accessory protein is an adeno-associated viral egress factor., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-26485-4] [abs].
  • Havlik, LP; Das, A; Mietzsch, M; Oh, DK; Ark, J; McKenna, R; Agbandje-McKenna, M; Asokan, A, Receptor Switching in Newly Evolved Adeno-associated Viruses., J Virol, vol 95 no. 19 (2021) [10.1128/JVI.00587-21] [abs].
  • Gemberling, MP; Siklenka, K; Rodriguez, E; Tonn-Eisinger, KR; Barrera, A; Liu, F; Kantor, A; Li, L; Cigliola, V; Hazlett, MF; Williams, CA; Bartelt, LC; Madigan, VJ; Bodle, JC; Daniels, H; Rouse, DC; Hilton, IB; Asokan, A; Ciofani, M; Poss, KD; Reddy, TE; West, AE; Gersbach, CA, Transgenic mice for in vivo epigenome editing with CRISPR-based systems., Nat Methods, vol 18 no. 8 (2021), pp. 965-974 [10.1038/s41592-021-01207-2] [abs].