Anoop Patel

Associate Professor of Neurosurgery

Appointments and Affiliations

  • Associate Professor of Neurosurgery
  • Associate Professor in Pathology
  • Associate Professor of Biomedical Engineering
  • Member of the Duke Cancer Institute

Contact Information

  • Email Address: anoop.patel@duke.edu

Education

  • M.D. Harvard Medical School, 2009

Research Interests

My research lab focuses on using single-cell sequencing techniques to study intratumoral heterogeneity in malignant brain tumors. Intratumoral heterogeneity is the idea that individual cancer cells within a patient’s tumor are different and can respond differently to treatments. I also have an active interest in developing patient-specific models of disease where we can learn how an individual patient's tumor might respond differently than another. My ultimate goal is to further advance precision medicine approaches for malignant brain tumors, and ensure that patients are getting the right treatments for their specific tumors.

Courses Taught

  • UPGEN 778F: University Program in Genetics and Genomics Biological Solutions Module VI
  • EGR 393: Research Projects in Engineering
  • BME 791: Graduate Independent Study

Representative Publications

  • McGee James, Tristen, Mohamed-Yahia Monawar, Eric Shaker, Aden P. Haskell-Mendoza, Ariel Gonzalez, Pakawat Chongsathidkiet, Tara Dalton, et al. “Evolution of randomized controlled trials in adult neurosurgical critical care from 1990 to 2024 in the United States.” Neurosurg Rev 49, no. 1 (July 14, 2026). https://doi.org/10.1007/s10143-026-04389-5.
  • Shen, Steven, Aditya A. Mohan, Kelly M. Hotchkiss, Sarah Cook, Kisha Patel, Eliese Moelker, Bhairavy Puviindran, et al. “IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma.” J Immunother Cancer 14, no. 3 (March 24, 2026). https://doi.org/10.1136/jitc-2025-012532.
  • Hoyt-Miggelbrink, Alexandra M., Jessica Waibl Polania, Luke Wachsmuth, Selena Lorrey, Aditya Mohan, Andrew Hardigan, Emily Blandford, et al. “Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.” Clin Cancer Res 32, no. 4 (February 17, 2026): 782–800. https://doi.org/10.1158/1078-0432.CCR-24-3455.
  • Radaelli, Cristina, Matthew Schmitz, Xiao-Ping Liu, Scott Sawchuk, Ximena Opitz-Araya, Mark Hudson, Naz Taskin, et al. “HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species.” Commun Biol 9, no. 1 (January 20, 2026): 279. https://doi.org/10.1038/s42003-026-09558-2.
  • Singh, Kirit, Matthew W. Foster, Marlene J. Violette, Anna M. Corcoran, Kelly M. Hotchkiss, Chelsea O. Railton, Emily E. Blandford, et al. “A surgical window of opportunity trial evaluating the effect of the PCSK9 inhibitor evolocumab on tumoral MHC-I expression and CD8+ infiltration in glioma.” Sci Rep 15, no. 1 (October 23, 2025): 37112. https://doi.org/10.1038/s41598-025-21064-9.