Associate Professor of Neurosurgery
Appointments and Affiliations
- Associate Professor of Neurosurgery
- Associate Professor in Pathology
- Member of the Duke Cancer Institute
Contact Information
- Email Address: anoop.patel@duke.edu
Education
- M.D. Harvard Medical School, 2009
Research Interests
My research lab focuses on using single-cell sequencing techniques to study intratumoral heterogeneity in malignant brain tumors. Intratumoral heterogeneity is the idea that individual cancer cells within a patient’s tumor are different and can respond differently to treatments. I also have an active interest in developing patient-specific models of disease where we can learn how an individual patient's tumor might respond differently than another. My ultimate goal is to further advance precision medicine approaches for malignant brain tumors, and ensure that patients are getting the right treatments for their specific tumors.
Representative Publications
- Hotchkiss, Kelly M., Philipp Karschnia, Karisa C. Schreck, Marjolein Geurts, Timothy F. Cloughesy, Jason Huse, Elizabeth S. Duke, et al. “A brave new framework for glioma drug development.” Lancet Oncol 25, no. 10 (October 2024): e512–19. https://doi.org/10.1016/S1470-2045(24)00190-6.
- Park, James H., Parvinder Hothi, Adrian Lopez Garcia de Lomana, Min Pan, Rachel Calder, Serdar Turkarslan, Wei-Ju Wu, et al. “Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.” Sci Adv 10, no. 23 (June 7, 2024): eadj7706. https://doi.org/10.1126/sciadv.adj7706.
- Liu, Mengyi, Zhicheng Ji, Vaibhav Jain, Vanessa L. Smith, Emily Hocke, Anoop P. Patel, Roger E. McLendon, David M. Ashley, Simon G. Gregory, and Giselle Y. López. “Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche.” Acta Neuropathol Commun 12, no. 1 (April 22, 2024): 64. https://doi.org/10.1186/s40478-024-01769-0.
- Nuechterlein, Nicholas, Allison Shelbourn, Frank Szulzewsky, Sonali Arora, Michelle Casad, Siobhan Pattwell, Leyre Merino-Galan, et al. “Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.” Genes Dev 38, no. 5–6 (April 17, 2024): 273–88. https://doi.org/10.1101/gad.351350.123.
- Hardigan, Andrew A., Joshua D. Jackson, and Anoop P. Patel. “Surgical Management and Advances in the Treatment of Glioma.” Semin Neurol 43, no. 6 (December 2023): 810–24. https://doi.org/10.1055/s-0043-1776766.