Aravind Asokan

Professor in Surgery

Synthetic Virology & Gene Therapy

Appointments and Affiliations

  • Professor in Surgery
  • Director of Gene Therapy
  • Professor of Molecular Genetics and Microbiology
  • Professor of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. University of North Carolina, Chapel Hill, 2004

Research Interests

Virology
RNA Biology
Viral Engineering
RNA Engineering
Gene Therapy
Gene Editing
Gene Regulation
Regenerative Medicine

Awards, Honors, and Distinctions

  • Fellow (NAI). National Academy of Inventors. 2025

Courses Taught

  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Wu, Helen L., Gabriela M. Webb, Sebastian P. Fuchs, Cleiton T. Pessoa, Joseph M. Hwang, Hannah K. Fisher, Allyson J. McCullen, et al. “Adeno-associated virus gene therapy-mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques.” Sci Transl Med 18, no. 847 (April 29, 2026): eadw1976. https://doi.org/10.1126/scitranslmed.adw1976.
  • Brown, David A., Katja K. Koll, Erin Brush, Grant Darner, Timothy Curtis, Thomas Dvergsten, Melissa Tran, et al. “Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.” Proc Natl Acad Sci U S A 123, no. 17 (April 28, 2026): e2532804123. https://doi.org/10.1073/pnas.2532804123.
  • Nyberg, William A., Pierre-Louis Bernard, Wayne Ngo, Charlotte H. Wang, Jonathan Ark, Allison Rothrock, Gina M. Borgo, et al. “In vivo site-specific engineering to reprogram T cells.” Nature 652, no. 8110 (April 2026): 712–21. https://doi.org/10.1038/s41586-026-10235-x.
  • Hickman, Peyton G., Aravind Asokan, and Matthew H. Wilson. “Rewriting Renal Fate: The Evolving Landscape of Adeno-Associated Virus-Mediated Kidney Gene Therapies.” Kidney360 7, no. 2 (February 1, 2026): 422–25. https://doi.org/10.34067/KID.0000001119.
  • Loeb, Ezra J., Sophia A. Fergione, Vivian Yudistyra, Marco M. Fanous, Abigail R. Benkert, Delaney G. Fisher, Joshua A. Hull, Mai K. ElMallah, and Aravind Asokan. “Complete neutralizing antibody evasion by serodivergent non-mammalian AAVs enables gene therapy redosing.” Cell Rep Med 6, no. 12 (December 16, 2025): 102475. https://doi.org/10.1016/j.xcrm.2025.102475.