Dmitry Velmeshev

Assistant Professor of Neurobiology

The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level.​ We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors that give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.

Appointments and Affiliations

  • Assistant Professor of Neurobiology
  • Assistant Professor of Biomedical Engineering

Contact Information

  • Email Address: dmitry.velmeshev@duke.edu

Education

  • Ph.D. University of Miami, 2016

Courses Taught

  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 493: Research Independent Study 1
  • NEUROBIO 790S: Student Seminar (Topics)
  • NEUROBIO 735: Quantitative Approaches in Neurobiology
  • CMB 710F: Cell & Molecular Biology Module VI
  • CMB 710E: Cell & Molecular Biology Module V

Representative Publications

  • Gao, Yudong, Daichi Shonai, Matthew Trn, Jieqing Zhao, Erik J. Soderblom, S Alexandra Garcia-Moreno, Charles A. Gersbach, et al. “Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.” Nat Commun 15, no. 1 (August 9, 2024): 6801. https://doi.org/10.1038/s41467-024-51037-x.
  • Yuan, Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, et al. “Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.” Mol Neurodegener 19, no. 1 (June 11, 2024): 47. https://doi.org/10.1186/s13024-024-00738-4.
  • Velmeshev, Dmitry, Yonatan Perez, Zihan Yan, Jonathan E. Valencia, David R. Castaneda-Castellanos, Li Wang, Lucas Schirmer, et al. “Single-cell analysis of prenatal and postnatal human cortical development.” Science 382, no. 6667 (October 13, 2023): eadf0834. https://doi.org/10.1126/science.adf0834.
  • Marsan, Elise, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, et al. “Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.” J Clin Invest 133, no. 6 (March 15, 2023). https://doi.org/10.1172/JCI164919.
  • Trobisch, Tim, Amel Zulji, Nikolas A. Stevens, Sophia Schwarz, Sven Wischnewski, Mikail Öztürk, Javier Perales-Patón, et al. “Cross-regional homeostatic and reactive glial signatures in multiple sclerosis.” Acta Neuropathol 144, no. 5 (November 2022): 987–1003. https://doi.org/10.1007/s00401-022-02497-2.