Pranam D. Chatterjee

Assistant Professor of Biomedical Engineering

Appointments and Affiliations

  • Assistant Professor of Biomedical Engineering
  • Assistant Professor in Biostatistics & Bioinformatics
  • Assistant Professor of Computer Science

Contact Information

  • Office Location: 101 Science Drive, Ciemas 2353A, Durham, NC 27705
  • Office Phone: +1 706 442 2715
  • Email Address:
  • Websites:


  • Ph.D. Massachusetts Institute of Technology, 2020

Research Interests

Integration of computational and experimental methodologies to design novel proteins for applications in genome editing, targeted protein modulation, and reproductive bioengineering

Courses Taught

  • EGR 393: Research Projects in Engineering
  • COMPSCI 590: Advanced Topics in Computer Science
  • COMPSCI 394: Research Independent Study
  • BME 791: Graduate Independent Study
  • BME 789: Internship in Biomedical Engineering
  • BME 590: Special Topics in Biomedical Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 390L: Special Topics with a Lab

In the News

Representative Publications

  • Peng, Zhangzhi, Benjamin Schussheim, and Pranam Chatterjee. “PTM-Mamba: A PTM-Aware Protein Language Model with Bidirectional Gated Mamba Blocks.” BioRxiv, 2024.
  • Chen, T., L. Hong, V. Yudistyra, S. Vincoff, and P. Chatterjee. “Generative design of therapeutics that bind and modulate protein states.” Current Opinion in Biomedical Engineering 28 (December 1, 2023).
  • Zhao, Lin, Sabrina R. T. Koseki, Rachel A. Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, et al. “PAM-flexible genome editing with an engineered chimeric Cas9.” Nature Communications 14, no. 1 (October 2023): 6175.
  • Brixi, Garyk, Tianzheng Ye, Lauren Hong, Tian Wang, Connor Monticello, Natalia Lopez-Barbosa, Sophia Vincoff, et al. “SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders.” Communications Biology 6, no. 1 (October 2023): 1081.
  • Liang, Shun-Qing, Pengpeng Liu, Karthikeyan Ponnienselvan, Sneha Suresh, Zexiang Chen, Christian Kramme, Pranam Chatterjee, et al. “Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.” Nature Methods 20, no. 6 (June 2023): 898–907.