Margaret Harris and David Silverman Distinguished Professor
Dr. Gregory is the Margaret Harris and David Silverman Distinguished Professor and Director of the Brain Tumor Omics Program in the Duke Department of Neurosurgery, the Vice Chair of Research in the Department of Neurology, and Director of the Molecular Genomics Core at the Duke Molecular Physiology Institute.
As a neurogenomicist, Dr. Gregory applies the experience gained from leading the sequencing of chromosome 1 for the Human Genome Project to elucidating the mechanisms underlying multi-factorial diseases using genetic, genomic, and epigenetic approaches. Dr. Gregory’s primary areas of research involve understanding the molecular processes associated with disease development and progression in brain tumors and Alzheimer’s disease, drug induced white matter injury repair in multiple sclerosis, and the characterization of lesion microenvironmental changes in MS.
He is broadly regarded across Duke as a leader in the development of novel single cell and spatial molecular technologies towards understanding the pathogenic mechanisms of disease development. Dr. Gregory is also the Section Chair of Genomics and Epigenetics at the DMPI and Director of the Duke Center of Autoimmunity and MS in the Department of Neurology.
Appointments and Affiliations
- Margaret Harris and David Silverman Distinguished Professor
- Professor in Neurosurgery
- Vice Chair for Research in the Department of Neurology
- Professor in Neurology
- Professor in Molecular Genetics and Microbiology
- Member of Duke Molecular Physiology Institute
- Member of the Duke Cancer Institute
Contact Information
- Office Location: 300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701
- Email Address: simon.gregory@duke.edu
- Websites:
Education
- B.A.Sc. RMIT University (Australia), 1990
- Ph.D. Open University, Milton Keynes (United Kingdom), 2003
Research Interests
Brain tumors
Multiple Sclerosis
Autism
Alzheimer Disease
Application of single cell and spatial technologies to basic and translational research
Awards, Honors, and Distinctions
- Nominated, Outstanding Postdoc Mentor. Duke University. 2015
- Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
- Breakthrough Research Award. North Carolina Health & Life Science. 2010
- Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007
Courses Taught
- UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il
In the News
- Duke Awards 32 New Distinguished Professorships for 2024 (Mar 19, 2024 | Duke T…
- Alzheimer's Research: Unlocking the Secrets of the Brain (Mar 20, 2022)
- New Gene Interaction Appears to be Associated with Increased MS Risk (Mar 23, 2…
- Mapping the Biology of Drug-Resistant Multiple Sclerosis (Nov 7, 2016)
- Allen Song Named Interim Director of Brain Institute (Jun 26, 2015)
- Simon Gregory quoted: More evidence that parents' ages could influence autism r…
- Simon Gregory Inducted to MS Hall of Fame (Nov 21, 2014)
- Community comes together for 9-year-old with rare condition (Sep 25, 2013 | WRA…
- Study finds link between induced labor and autism diagnoses (Aug 13, 2013 | Wal…
- Induced labor 'linked to autism' (Aug 13, 2013 | BBC News)
- Inducing and Augmenting Labor May be Associated with Increased Risk of Autism (…
- Autism linked to induced or augmented labor, study says (Aug 13, 2013 | CNN)
Representative Publications
- Minear, Mollie A., David R. Crosslin, Beth S. Sutton, Jessica J. Connelly, Sarah C. Nelson, Shera Gadson-Watson, Tianyuan Wang, et al. “Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.” Hum Genet 129, no. 6 (June 2011): 641–54. https://doi.org/10.1007/s00439-011-0959-z.
- Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases.” RNA Biol 7, no. 4 (2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.
- Gregory, Simon G., Jessica J. Connelly, Aaron J. Towers, Jessica Johnson, Dhani Biscocho, Christina A. Markunas, Carla Lintas, et al. “Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.” BMC Med 7 (October 22, 2009): 62. https://doi.org/10.1186/1741-7015-7-62.
- Connelly, Jessica J., Svati H. Shah, Jennifer F. Doss, Shera Gadson, Sarah Nelson, David R. Crosslin, A Brent Hale, et al. “Genetic and functional association of FAM5C with myocardial infarction.” BMC Med Genet 9 (April 22, 2008): 33. https://doi.org/10.1186/1471-2350-9-33.
- Gregory, Simon G., Silke Schmidt, Puneet Seth, Jorge R. Oksenberg, John Hart, Angela Prokop, Stacy J. Caillier, et al. “Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.” Nat Genet 39, no. 9 (September 2007): 1083–91. https://doi.org/10.1038/ng2103.
- Connelly, Jessica J., Tianyuan Wang, Julie E. Cox, Carol Haynes, Liyong Wang, Svati H. Shah, David R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.” PLoS Genet 2, no. 8 (August 25, 2006): e139. https://doi.org/10.1371/journal.pgen.0020139.
- Schmidt, S., M. A. Pericak-Vance, S. Sawcer, L. F. Barcellos, J. Hart, J. Sims, A. M. Prokop, et al. “Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.” Genes Immun 7, no. 5 (July 2006): 384–92. https://doi.org/10.1038/sj.gene.6364311.
- Gregory, S. G., K. F. Barlow, K. E. McLay, R. Kaul, D. Swarbreck, A. Dunham, C. E. Scott, et al. “The DNA sequence and biological annotation of human chromosome 1.” Nature 441, no. 7091 (May 18, 2006): 315–21. https://doi.org/10.1038/nature04727.
- Gregory, Simon G., Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, et al. “A physical map of the mouse genome.” Nature 418, no. 6899 (August 15, 2002): 743–50. https://doi.org/10.1038/nature00957.