Assistant Professor of Biostatistics & Bioinformatics
William H. Majoros, PhD, is an Assistant Professor of Biostatistics and Bioinformatics.
Appointments and Affiliations
- Assistant Professor of Biostatistics & Bioinformatics
Contact Information
- Office Location: 101 Science Drive, 2187 CIEMAS, Research Drive, Durham, NC 27708
- Email Address: william.majoros@duke.edu
Education
- Ph.D. Duke University, 2017
Research Interests
- Probabilistic machine learning
- Bayesian graphical models
- Structured prediction
- Interpretation/prioritization of genetic variants in disease
- RNA splicing
- Gene regulation
- Computational linguistics - formal grammars and parsing
- Syntactic structure and memetic evolution in complex bird song
Courses Taught
- COMPSCI 763: Graphical Models for Biological Data
- COMPSCI 561: Computational Sequence Biology
- COMPSCI 394: Research Independent Study
- COMPSCI 393: Research Independent Study
- COMPSCI 260: Introduction to Computational Genomics
- CBB 914: Graphical Models for Biological Data
- CBB 561: Computational Sequence Biology
- BIOSTAT 914: Graphical Models for Biological Data
- BIOSTAT 707: Statistical Methods for Learning and Discovery
Representative Publications
- Li, Daofeng, Shane Liu, Pedro R. Assis, Mingjie Li, Shengcheng Dong, Ian Whaling, Otto Jolanki, et al. “The IGVF catalog-from genetic variation to function.” Nucleic Acids Res, December 8, 2025. https://doi.org/10.1093/nar/gkaf1341.
- Iyengar, Apoorva K., Xue Zou, Jian Dai, Rhodricia A. Francis, Alexias Safi, Karynne Patterson, Rebecca L. Koch, et al. “Cell Modeling and Rescue of a Novel Non-coding Genetic Cause of Glycogen Storage Disease IX.” Genetics in Medicine Open, November 2025, 103474–103474. https://doi.org/10.1016/j.gimo.2025.103474.
- Zou, Xue, Zachary W. Gomez, Timothy E. Reddy, Andrew S. Allen, and William H. Majoros. “Bayesian estimation of allele-specific expression in the presence of phasing uncertainty.” Bioinformatics 41, no. 6 (June 2, 2025). https://doi.org/10.1093/bioinformatics/btaf283.
- Iyengar, Apoorva K., Xue Zou, Jian Dai, Rhodricia A. Francis, Alexias Safi, Karynne Patterson, Rebecca L. Koch, et al. “Cell Modeling and Rescue of a Novel Non-coding Genetic Cause of Glycogen Storage Disease IX.,” May 17, 2025. https://doi.org/10.1101/2025.05.14.654043.
- Liu, Siyan, Marisa C. Hamilton, Thomas Cowart, Alejandro Barrera, Lexi R. Bounds, Alexander C. Nelson, Sophie F. Dornbaum, et al. “Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER.” Cell Genom 5, no. 2 (February 12, 2025): 100766. https://doi.org/10.1016/j.xgen.2025.100766.