Simon Gray Gregory
Professor in Neurology
My principal area of research involves elucidating the molecular mechanisms underlying multi-factorial diseases. My lab is primarily interested identifying the complex genetic factors that give rise to multiple sclerosis (MS) and autism. We are using targeted approaches to identify differential methylation of the oxytocin receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spray to improve social reciprocity in 300 children with autism, and for which we are developing e/genetic and transcriptomic predictors of response and effects of long term drug exposure.
My MS laboratory at Duke University is using cell signaling and immune cell flow sorting to establish the role of IL7R signaling in the development of MS; we are exploring the use of high sensitivity assays to develop a trajectory of disease development in progressive MS; we are exploring the use of endogenous oxysterols to trigger remyelination of white matter injury in MS; and establishing the immune expression and receptor profile of MS patients who do or do not respond to drug treatment.
I am PI of the MURDOCK-MS collection, a cross sectional MS cohort of ~1000 MS patients that will provide the basis for genetic, genomic and metabolomic biomarker identification of MS disease development and progression. I am Director of the Duke Center for Research in Autoimmunity and MS within the Duke Department of Neurology, and also Director of the Molecular Genomics Core at the DMPI in which we are applying a panoply of single cell approaches to basic and translation research.
Appointments and Affiliations
- Professor in Neurology
- Research Professor in Molecular Genetics and Microbiology
- Professor in Molecular Genetics and Microbiology
- Member of the Duke Cancer Institute
- Member of Duke Molecular Physiology Institute
- Office Location: 300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701
- Office Phone: (919) 684-0726
- Email Address: email@example.com
- Ph.D. Open University, Milton Keynes (United Kingdom), 2003
- B.A.Sc. RMIT University (Australia), 1990
Coronary Artery Disease
Prostate and Lung cancer
Epigenetics of human disease
Application of single cell technologies to basic and translational research
Precision medicine of neurological disease
Awards, Honors, and Distinctions
- Nominated, Outstanding Postdoc Mentor. Duke University. 2015
- Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
- Breakthrough Research Award. North Carolina Health & Life Science. 2010
- Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007
- BIOLOGY 728A: University Program in Genetics and Genomics Biological Solutions Module I
- CMB 778A: University Program in Genetics and Genomics Biological Solutions Module I
- CRP 243: Introduction to Medical Genetics
- MGM 593: Research Independent Study
- MGM 778A: University Program in Genetics and Genomics Biological Solutions Module I
- UPGEN 778A: University Program in Genetics and Genomics Biological Solutions Module I
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV
In the News
- New Gene Interaction Appears to be Associated with Increased MS Risk (Mar 23, 2017 | Duke Health News)
- Mapping the Biology of Drug-Resistant Multiple Sclerosis (Nov 7, 2016)
- Allen Song Named Interim Director of Brain Institute (Jun 26, 2015)
- Simon Gregory quoted: More evidence that parents' ages could influence autism risk (Jun 11, 2015 | NPR)
- Simon Gregory Inducted to MS Hall of Fame (Nov 21, 2014)
- Community comes together for 9-year-old with rare condition (Sep 25, 2013 | WRAL)
- Inducing and Augmenting Labor May be Associated with Increased Risk of Autism (Aug 13, 2013)
- Induced labor 'linked to autism' (Aug 13, 2013 | BBC News)
- Autism linked to induced or augmented labor, study says (Aug 13, 2013 | CNN)
- Study finds link between induced labor and autism diagnoses (Aug 13, 2013 | Wall Street Journal)
- Minear, MA; Crosslin, DR; Sutton, BS; Connelly, JJ; Nelson, SC; Gadson-Watson, S; Wang, T; Seo, D; Vance, JM; Sketch, MH; Haynes, C; Goldschmidt-Clermont, PJ; Shah, SH; Kraus, WE; Hauser, ER; Gregory, SG, Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease., Hum Genet, vol 129 no. 6 (2011), pp. 641-654 [10.1007/s00439-011-0959-z] [abs].
- Evsyukova, I; Somarelli, JA; Gregory, SG; Garcia-Blanco, MA, Alternative splicing in multiple sclerosis and other autoimmune diseases., Rna Biol, vol 7 no. 4 (2010), pp. 462-473 [10.4161/rna.7.4.12301] [abs].
- Gregory, SG; Connelly, JJ; Towers, AJ; Johnson, J; Biscocho, D; Markunas, CA; Lintas, C; Abramson, RK; Wright, HH; Ellis, P; Langford, CF; Worley, G; Delong, GR; Murphy, SK; Cuccaro, ML; Persico, A; Pericak-Vance, MA, Genomic and epigenetic evidence for oxytocin receptor deficiency in autism., Bmc Medicine, vol 7 (2009) [10.1186/1741-7015-7-62] [abs].
- Connelly, JJ; Shah, SH; Doss, JF; Gadson, S; Nelson, S; Crosslin, DR; Hale, AB; Lou, X; Wang, T; Haynes, C; Seo, D; Crossman, DC; Mooser, V; Granger, CB; Jones, CJH; Kraus, WE; Hauser, ER; Gregory, SG, Genetic and functional association of FAM5C with myocardial infarction., Bmc Medical Genetics, vol 9 (2008) [10.1186/1471-2350-9-33] [abs].
- Gregory, SG; Schmidt, S; Seth, P; Oksenberg, JR; Hart, J; Prokop, A; Caillier, SJ; Ban, M; Goris, A; Barcellos, LF; Lincoln, R; McCauley, JL; Sawcer, SJ; Compston, DAS; Dubois, B; Hauser, SL; Garcia-Blanco, MA; Pericak-Vance, MA; Haines, JL; Multiple Sclerosis Genetics Group,, Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis., Nature Genetics, vol 39 no. 9 (2007), pp. 1083-1091 [10.1038/ng2103] [abs].
- Connelly, JJ; Wang, T; Cox, JE; Haynes, C; Wang, L; Shah, SH; Crosslin, DR; Hale, AB; Nelson, S; Crossman, DC; Granger, CB; Haines, JL; Jones, CJH; Vance, JM; Goldschmidt-Clermont, PJ; Kraus, WE; Hauser, ER; Gregory, SG, GATA2 is associated with familial early-onset coronary artery disease., Plos Genet, vol 2 no. 8 (2006) [10.1371/journal.pgen.0020139] [abs].
- Schmidt, S; Pericak-Vance, MA; Sawcer, S; Barcellos, LF; Hart, J; Sims, J; Prokop, AM; van der Walt, J; DeLoa, C; Lincoln, RR; Oksenberg, JR; Compston, A; Hauser, SL; Haines, JL; Gregory, SG; Multiple Sclerosis Genetics Group,, Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis., Genes and Immunity, vol 7 no. 5 (2006), pp. 384-392 [10.1038/sj.gene.6364311] [abs].
- Gregory, SG; Barlow, KF; McLay, KE; Kaul, R; Swarbreck, D; Dunham, A; Scott, CE; Howe, KL; Woodfine, K; Spencer, CCA; Jones, MC; Gillson, C; Searle, S; Zhou, Y; Kokocinski, F; McDonald, L; Evans, R; Phillips, K; Atkinson, A; Cooper, R; Jones, C; Hall, RE; Andrews, TD; Lloyd, C; Ainscough, R; Almeida, JP; Ambrose, KD; Anderson, F; Andrew, RW; Ashwell, RIS; Aubin, K; Babbage, AK; Bagguley, CL; Bailey, J; Beasley, H; Bethel, G; Bird, CP; Bray-Allen, S; Brown, JY; Brown, AJ; Buckley, D; Burton, J; Bye, J; Carder, C; Chapman, JC; Clark, SY; Clarke, G; Clee, C; Cobley, V; Collier, RE; Corby, N; Coville, GJ; Davies, J; Deadman, R; Dunn, M; Earthrowl, M; Ellington, AG; Errington, H; Frankish, A; Frankland, J; French, L; Garner, P; Garnett, J; Gay, L; Ghori, MRJ; Gibson, R; Gilby, LM; Gillett, W; Glithero, RJ; Grafham, DV; Griffiths, C; Griffiths-Jones, S; Grocock, R; Hammond, S; Harrison, ESI; Hart, E; Haugen, E; Heath, PD; Holmes, S; Holt, K; Howden, PJ; Hunt, AR; Hunt, SE; Hunter, G; Isherwood, J; James, R; Johnson, C; Johnson, D; Joy, A; Kay, M; Kershaw, JK; Kibukawa, M; Kimberley, AM; King, A; Knights, AJ; Lad, H; Laird, G; Lawlor, S; Leongamornlert, DA; Lloyd, DM; Loveland, J; Lovell, J; Lush, MJ; Lyne, R; Martin, S; Mashreghi-Mohammadi, M; Matthews, L; Matthews, NSW; McLaren, S; Milne, S; Mistry, S; Moore, MJF; Nickerson, T; O'Dell, CN; Oliver, K; Palmeiri, A; Palmer, SA; Parker, A; Patel, D; Pearce, AV; Peck, AI; Pelan, S; Phelps, K; Phillimore, BJ; Plumb, R; Rajan, J; Raymond, C; Rouse, G; Saenphimmachak, C; Sehra, HK; Sheridan, E; Shownkeen, R; Sims, S; Skuce, CD; Smith, M; Steward, C; Subramanian, S; Sycamore, N; Tracey, A; Tromans, A; Van Helmond, Z; Wall, M; Wallis, JM; White, S; Whitehead, SL; Wilkinson, JE; Willey, DL; Williams, H; Wilming, L; Wray, PW; Wu, Z; Coulson, A; Vaudin, M; Sulston, JE; Durbin, R; Hubbard, T; Wooster, R; Dunham, I; Carter, NP; McVean, G; Ross, MT; Harrow, J; Olson, MV; Beck, S; Rogers, J; Bentley, DR; Banerjee, R; Bryant, SP; Burford, DC; Burrill, WDH; Clegg, SM; Dhami, P; Dovey, O; Faulkner, LM; Gribble, SM; Langford, CF; Pandian, RD; Porter, KM; Prigmore, E, The DNA sequence and biological annotation of human chromosome 1., Nature, vol 441 no. 7091 (2006), pp. 315-321 [10.1038/nature04727] [abs].
- Gregory, SG; Sekhon, M; Schein, J; Zhao, S; Osoegawa, K; Scott, CE; Evans, RS; Burridge, PW; Cox, TV; Fox, CA; Hutton, RD; Mullenger, IR; Phillips, KJ; Smith, J; Stalker, J; Threadgold, GJ; Birney, E; Wylie, K; Chinwalla, A; Wallis, J; Hillier, L; Carter, J; Gaige, T; Jaeger, S; Kremitzki, C; Layman, D; Maas, J; McGrane, R; Mead, K; Walker, R; Jones, S; Smith, M; Asano, J; Bosdet, I; Chan, S; Chittaranjan, S; Chiu, R; Fjell, C; Fuhrmann, D; Girn, N; Gray, C; Guin, R; Hsiao, L; Krzywinski, M; Kutsche, R; Lee, SS; Mathewson, C; McLeavy, C; Messervier, S; Ness, S; Pandoh, P; Prabhu, A-L; Saeedi, P; Smailus, D; Spence, L; Stott, J; Taylor, S; Terpstra, W; Tsai, M; Vardy, J; Wye, N; Yang, G; Shatsman, S; Ayodeji, B; Geer, K; Tsegaye, G; Shvartsbeyn, A; Gebregeorgis, E; Krol, M; Russell, D; Overton, L; Malek, JA; Holmes, M; Heaney, M; Shetty, J; Feldblyum, T; Nierman, WC; Catanese, JJ; Hubbard, T; Waterston, RH; Rogers, J; de Jong, PJ; Fraser, CM; Marra, M; McPherson, JD; Bentley, DR, A physical map of the mouse genome., Nature, vol 418 no. 6899 (2002), pp. 743-750 [10.1038/nature00957] [abs].