Simon Gray Gregory


Professor in Neurology

My research involves elucidating the molecular mechanisms underlying complex neurological diseases, such as multiple sclerosis (MS), autism, Alzheimer's disease (AD), and brain tumors. We use a variety of (epi)genetic, genomic, transcriptomic, and leading edge technologies to identify the underpinnings of disease development and progression. 

With respect to autism, we are investigating the use of oxytocin to improve social reciprocity in children with the disorder and developing (epi)genetic and transcriptomic predictors of plasma levels of oxytocin. We are also unraveling the mechanisms associated with sociability in animal models of autism.

In the fields of AD and brain tumor research, my lab is using or developing leading edge single cell and spatial expression profiling platforms to unravel the molecular mechanisms of pathology or tissue related microenvironmental changes associated with disease development and progression.

My MS laboratory at Duke University is exploring the use of high sensitivity assays to develop a trajectory of disease development in progressive MS; we are exploring the use of endogenous oxysterols to trigger remyelination of white matter injury in MS; and establishing the immune expression and receptor profile in stable or progressive MS patients. I am PI of the MURDOCK-MS collection, a cross sectional MS cohort of ~1000 MS patients that will provide the basis for genetic, genomic and metabolomic biomarker identification of MS disease development and progression. I am Director of the Duke Center for Research in Autoimmunity and MS within the Duke Department of Neurology.

Appointments and Affiliations

  • Professor in Neurology
  • Research Professor in Molecular Genetics and Microbiology
  • Professor in Molecular Genetics and Microbiology
  • Member of the Duke Cancer Institute
  • Member of Duke Molecular Physiology Institute

Contact Information


  • Ph.D. Open University, Milton Keynes (United Kingdom), 2003
  • B.A.Sc. RMIT University (Australia), 1990

Research Interests

Multiple Sclerosis


Brain tumors

Alzheimer Disease

Application of single cell and spatial technologies to basic and translational research

Awards, Honors, and Distinctions

  • Nominated, Outstanding Postdoc Mentor. Duke University. 2015
  • Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
  • Breakthrough Research Award. North Carolina Health & Life Science. 2010
  • Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007

Courses Taught

  • CRP 243: Introduction to Medical Genetics
  • MGM 593: Research Independent Study
  • UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill
  • UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV

In the News

Representative Publications

  • Minear, MA; Crosslin, DR; Sutton, BS; Connelly, JJ; Nelson, SC; Gadson-Watson, S; Wang, T; Seo, D; Vance, JM; Sketch, MH; Haynes, C; Goldschmidt-Clermont, PJ; Shah, SH; Kraus, WE; Hauser, ER; Gregory, SG, Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease., Hum Genet, vol 129 no. 6 (2011), pp. 641-654 [10.1007/s00439-011-0959-z] [abs].
  • Evsyukova, I; Somarelli, JA; Gregory, SG; Garcia-Blanco, MA, Alternative splicing in multiple sclerosis and other autoimmune diseases., Rna Biol, vol 7 no. 4 (2010), pp. 462-473 [10.4161/rna.7.4.12301] [abs].
  • Gregory, SG; Connelly, JJ; Towers, AJ; Johnson, J; Biscocho, D; Markunas, CA; Lintas, C; Abramson, RK; Wright, HH; Ellis, P; Langford, CF; Worley, G; Delong, GR; Murphy, SK; Cuccaro, ML; Persico, A; Pericak-Vance, MA, Genomic and epigenetic evidence for oxytocin receptor deficiency in autism., Bmc Medicine, vol 7 (2009) [10.1186/1741-7015-7-62] [abs].
  • Connelly, JJ; Shah, SH; Doss, JF; Gadson, S; Nelson, S; Crosslin, DR; Hale, AB; Lou, X; Wang, T; Haynes, C; Seo, D; Crossman, DC; Mooser, V; Granger, CB; Jones, CJH; Kraus, WE; Hauser, ER; Gregory, SG, Genetic and functional association of FAM5C with myocardial infarction., Bmc Medical Genetics, vol 9 (2008) [10.1186/1471-2350-9-33] [abs].
  • Gregory, SG; Schmidt, S; Seth, P; Oksenberg, JR; Hart, J; Prokop, A; Caillier, SJ; Ban, M; Goris, A; Barcellos, LF; Lincoln, R; McCauley, JL; Sawcer, SJ; Compston, DAS; Dubois, B; Hauser, SL; Garcia-Blanco, MA; Pericak-Vance, MA; Haines, JL; Multiple Sclerosis Genetics Group,, Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis., Nature Genetics, vol 39 no. 9 (2007), pp. 1083-1091 [10.1038/ng2103] [abs].
  • Connelly, JJ; Wang, T; Cox, JE; Haynes, C; Wang, L; Shah, SH; Crosslin, DR; Hale, AB; Nelson, S; Crossman, DC; Granger, CB; Haines, JL; Jones, CJH; Vance, JM; Goldschmidt-Clermont, PJ; Kraus, WE; Hauser, ER; Gregory, SG, GATA2 is associated with familial early-onset coronary artery disease., Plos Genet, vol 2 no. 8 (2006) [10.1371/journal.pgen.0020139] [abs].
  • Schmidt, S; Pericak-Vance, MA; Sawcer, S; Barcellos, LF; Hart, J; Sims, J; Prokop, AM; van der Walt, J; DeLoa, C; Lincoln, RR; Oksenberg, JR; Compston, A; Hauser, SL; Haines, JL; Gregory, SG; Multiple Sclerosis Genetics Group,, Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis., Genes and Immunity, vol 7 no. 5 (2006), pp. 384-392 [10.1038/sj.gene.6364311] [abs].
  • Gregory, SG; Barlow, KF; McLay, KE; Kaul, R; Swarbreck, D; Dunham, A; Scott, CE; Howe, KL; Woodfine, K; Spencer, CCA; Jones, MC; Gillson, C; Searle, S; Zhou, Y; Kokocinski, F; McDonald, L; Evans, R; Phillips, K; Atkinson, A; Cooper, R; Jones, C; Hall, RE; Andrews, TD; Lloyd, C; Ainscough, R; Almeida, JP; Ambrose, KD; Anderson, F; Andrew, RW; Ashwell, RIS; Aubin, K; Babbage, AK; Bagguley, CL; Bailey, J; Beasley, H; Bethel, G; Bird, CP; Bray-Allen, S; Brown, JY; Brown, AJ; Buckley, D; Burton, J; Bye, J; Carder, C; Chapman, JC; Clark, SY; Clarke, G; Clee, C; Cobley, V; Collier, RE; Corby, N; Coville, GJ; Davies, J; Deadman, R; Dunn, M; Earthrowl, M; Ellington, AG; Errington, H; Frankish, A; Frankland, J; French, L; Garner, P; Garnett, J; Gay, L; Ghori, MRJ; Gibson, R; Gilby, LM; Gillett, W; Glithero, RJ; Grafham, DV; Griffiths, C; Griffiths-Jones, S; Grocock, R; Hammond, S; Harrison, ESI; Hart, E; Haugen, E; Heath, PD; Holmes, S; Holt, K; Howden, PJ; Hunt, AR; Hunt, SE; Hunter, G; Isherwood, J; James, R; Johnson, C; Johnson, D; Joy, A; Kay, M; Kershaw, JK; Kibukawa, M; Kimberley, AM; King, A; Knights, AJ; Lad, H; Laird, G; Lawlor, S; Leongamornlert, DA; Lloyd, DM; Loveland, J; Lovell, J; Lush, MJ; Lyne, R; Martin, S; Mashreghi-Mohammadi, M; Matthews, L; Matthews, NSW; McLaren, S; Milne, S; Mistry, S; Moore, MJF; Nickerson, T; O'Dell, CN; Oliver, K; Palmeiri, A; Palmer, SA; Parker, A; Patel, D; Pearce, AV; Peck, AI; Pelan, S; Phelps, K; Phillimore, BJ; Plumb, R; Rajan, J; Raymond, C; Rouse, G; Saenphimmachak, C; Sehra, HK; Sheridan, E; Shownkeen, R; Sims, S; Skuce, CD; Smith, M; Steward, C; Subramanian, S; Sycamore, N; Tracey, A; Tromans, A; Van Helmond, Z; Wall, M; Wallis, JM; White, S; Whitehead, SL; Wilkinson, JE; Willey, DL; Williams, H; Wilming, L; Wray, PW; Wu, Z; Coulson, A; Vaudin, M; Sulston, JE; Durbin, R; Hubbard, T; Wooster, R; Dunham, I; Carter, NP; McVean, G; Ross, MT; Harrow, J; Olson, MV; Beck, S; Rogers, J; Bentley, DR; Banerjee, R; Bryant, SP; Burford, DC; Burrill, WDH; Clegg, SM; Dhami, P; Dovey, O; Faulkner, LM; Gribble, SM; Langford, CF; Pandian, RD; Porter, KM; Prigmore, E, The DNA sequence and biological annotation of human chromosome 1., Nature, vol 441 no. 7091 (2006), pp. 315-321 [10.1038/nature04727] [abs].
  • Gregory, SG; Sekhon, M; Schein, J; Zhao, S; Osoegawa, K; Scott, CE; Evans, RS; Burridge, PW; Cox, TV; Fox, CA; Hutton, RD; Mullenger, IR; Phillips, KJ; Smith, J; Stalker, J; Threadgold, GJ; Birney, E; Wylie, K; Chinwalla, A; Wallis, J; Hillier, L; Carter, J; Gaige, T; Jaeger, S; Kremitzki, C; Layman, D; Maas, J; McGrane, R; Mead, K; Walker, R; Jones, S; Smith, M; Asano, J; Bosdet, I; Chan, S; Chittaranjan, S; Chiu, R; Fjell, C; Fuhrmann, D; Girn, N; Gray, C; Guin, R; Hsiao, L; Krzywinski, M; Kutsche, R; Lee, SS; Mathewson, C; McLeavy, C; Messervier, S; Ness, S; Pandoh, P; Prabhu, A-L; Saeedi, P; Smailus, D; Spence, L; Stott, J; Taylor, S; Terpstra, W; Tsai, M; Vardy, J; Wye, N; Yang, G; Shatsman, S; Ayodeji, B; Geer, K; Tsegaye, G; Shvartsbeyn, A; Gebregeorgis, E; Krol, M; Russell, D; Overton, L; Malek, JA; Holmes, M; Heaney, M; Shetty, J; Feldblyum, T; Nierman, WC; Catanese, JJ; Hubbard, T; Waterston, RH; Rogers, J; de Jong, PJ; Fraser, CM; Marra, M; McPherson, JD; Bentley, DR, A physical map of the mouse genome., Nature, vol 418 no. 6899 (2002), pp. 743-750 [10.1038/nature00957] [abs].